Запись в SQLite3

import telebot
import sqlite3
import time
 
#Создали переменную бота
bot = telebot.TeleBot('5243181247:AAH3v5GnK7zsUGaHTZzcusCavHfQ2JzUTtA')
 
db = sqlite3.connect('database.db')
cur = db.cursor()
 
cur.execute('''CREATE TABLE IF NOT EXISTS patients(id INT,
            date TEXT,
            question1 TEXT,
            question21 TEXT,
            question22 TEXT,
            question23 TEXT,
            question24 TEXT,
            question25 TEXT,
            question26 TEXT,
            question27 TEXT,
            question28 TEXT,
            question29 TEXT,
            question210 TEXT,
            question211 TEXT,
            question212 TEXT,
            question213 TEXT,
            question214 TEXT,
            question3 TEXT,
            question4 TEXT,
            question5 TEXT,
            question61 TEXT,
            question62 TEXT,
            Comleted TEXT,
            firstinit TEXT,
            PRIMARY KEY(id,date))''')
cur.execute('''CREATE TABLE IF NOT EXISTS doctors(id INT,
            number TEXT,
            PRIMARY KEY(id))''')
cur.execute('''CREATE TABLE IF NOT EXISTS patientsnumbers(id INT,
            number TEXT,
            PRIMARY KEY(id))''') 
db.commit()
 
tconv = lambda x: time.strftime("%d.%m.%Y", time.localtime(x))
 
keyboard_answer1 = telebot.types.ReplyKeyboardMarkup(True)
keyboard_answer1.row('0','1','2','3','4','5')
keyboard_answer2 = telebot.types.ReplyKeyboardMarkup(True)
keyboard_answer2.row('0','1','2','3')
 
 
@bot.message_handler(commands=['start'])
def start_message(message):
  start_buttons = telebot.types.ReplyKeyboardMarkup(True)
  button_patient = telebot.types.KeyboardButton("Пaциeнт")
  button_doctor = telebot.types.KeyboardButton("Дoктop")
  start_buttons.add(button_patient,button_doctor)
  db = sqlite3.connect('database.db')
  cur = db.cursor()
  question1 = '0'
  question21 = '0'
  question22 = '0'
  question23 = '0'
  question24 = '0'
  question25 = '0'
  question26 = '0'
  question27 = '0'
  question28 = '0'
  question29 = '0'
  question210 = '0'
  question211 = '0'
  question212 = '0'
  question213 = '0'
  question214 = '0'
  question3 = '0'
  question4 = '0'
  question5 = '0'
  question61 = '0'
  question62 = '0'
  Completed = '0'
  firstinit = '0'
  date = str(tconv(message.date))
  sp = [message.chat.id, date,question1,question21,question22,question23,question24,question25,question26,question27,question28,question29,question210,question211,question212,question213,question214,question3,question4,question5,question61,question62,Completed,firstinit]
  cur.execute('''INSERT or REPLACE INTO patients VALUES(?,?,?,?,?,?,?,?,?,?,?,?,?,?,?,?,?,?,?,?,?,?,?,?);''',sp)
  db.commit()
  bot.send_message(message.chat.id,"Здравствуйте выберите необходимую категорию",reply_markup=start_buttons)
 
@bot.message_handler()
def prov(message):
  msg = message.text
  if msg == "Пaциeнт":
    menu2(message)
  if msg == "Дoктop":
    pass
  
def menu2(message):
  menu_buttons = telebot.types.InlineKeyboardMarkup()
  button_opros = telebot.types.InlineKeyboardButton("Прoйти oпрoc ", callback_data = 'b1')
  button_primarydata = telebot.types.InlineKeyboardButton("Пeрвичные дaнныe ", callback_data = 'b2')
  menu_buttons.add(button_opros,button_primarydata)
  bot.send_message(message.chat.id,'Выберите необходимую функцию',reply_markup=menu_buttons)
 
 
@bot.callback_query_handler(func = lambda call:True)
def answer(call):
  if call.data == 'b1': 
      bot.send_message(call.message.chat.id, '''Вопрос 1''',reply_markup = keyboard_answer1)
      msg5 = bot.send_message(call.message.chat.id,'Выбирайте варианты соответсвующие вашему состоянию')
      question1 = call.message.text
      db = sqlite3.connect('database.db')
      cur = db.cursor()
      date = str(tconv(call.message.date))
      sp = [question1]
      cur.execute('''REPLACE INTO patients(question1) VALUES(?);''',sp)
      db.commit()
      bot.register_next_step_handler(msg5,qu21)
      
  if call.data == 'b2':
    pass
 
def qu21(message):
          #Вопрос 2-1
  msg = bot.send_message(message.chat.id, '''Вопрос 2''',reply_markup = keyboard_answer2)
  question21 = message.text
  db = sqlite3.connect('database.db')
  cur = db.cursor()
  an21 = [question21]
  cur.execute('''REPLACE INTO patients(question21) VALUES(?);''',an21)
  db.commit()        
  bot.register_next_step_handler(msg,qu22)
 
def qu22(message):
  msg = bot.send_message(message.chat.id, '''Вопрос 3''',reply_markup = keyboard_answer2)
  question22 = message.text
  db = sqlite3.connect('database.db')
  cur = db.cursor()
  an22 = [question22]
  cur.execute('''REPLACE INTO patients(question22) VALUES(?);''',an22)
  db.commit()
  msg2 = bot.send_message(message.chat.id,'Опрос пройден')
  bot.register_next_step_handler(msg2,menu2)
          
bot.polling()

UPDATE patients SET(question1)=(?);