УДаление строки по конкретным символам

TARGET = "base.txt"
TARGET_FILE = "file.txt"
RESULT_FILE = "result.txt"
 
 
targets = []
with open(TARGET, "r", encoding='utf-16-le') as file:
    for target in file.readlines():
        targets.append(target.replace("\n", ""))
 
with open(RESULT_FILE, "a", encoding='utf-16-le') as result_file:
    save_lines = []
    with open(TARGET_FILE, "r", encoding='utf-16-le') as target_file:
        for line in target_file.readlines():
            for target in targets:
                if target in line:
                    result_file.write(line)
                    break
            else:
                save_lines.append(line)
    with open(TARGET_FILE, "w", encoding='utf-16-le') as target_file:
        target_file.writelines(save_lines)

>>> file = ['123', '123123', '123123123']
>>> base = ['123', '123123']
>>> result = list(filter(lambda x : x not in base, file))
>>> result
['123123123']
>>>

TARGET = "base.txt"
TARGET_FILE = "file.txt"
RESULT_FILE = "result.txt"
 
def file_read(name):
    with open(name) as file:
        return file.read().splitlines()
        
targets = file_read(TARGET)
target_file = file_read(TARGET_FILE)
result = '\n'.join(filter(lambda x : x not in targets, target_file))
 
with open(RESULT_FILE, "w") as result_file:
    result_file.write(result)

with open('file.txt', 'r') as file, open('base.txt', 'r') as base:
    l_file = file.read().split()
    b_file = base.read().split()
 
with open('file.txt', 'w') as file, open('result.txt', 'w') as result:
    for line in l_file:
        if line in b_file:
            result.write(line + '\n')
        else:
            file.write(line + '\n')